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Complex Traits and Polygenic Scores

Variable prediction accuracy of polygenic scores within an ancestry group (eLife)

Also see this eLife Digest and a VICE article highlighting some aspects of the paper.


Signals of adaptation of height, based on polygenic scores, are mostly an artifact of population structure confounding (eLife)

Also see this eLife editorial and article on Quanta Magazine covering the paper.

Selective constraint on gene expression (Genetics)


Statistical Learning about Molecular Processes


What determines the distribution of allele frequencies in humans in large samples?  We found surprising effects of two evolutionary forces, mutation rate variation and fitness epistasis. (PLoS Genetics)

Also see a highlight of the paper at F1000Prime.


Frequent non-allelic gene conversion on the human lineage, yet “concerted evolution” is rare (PNAS)

1000s of novel coding sequences in humans identified with Ribosome profiling (eLife)

The Role of Natural Selection in Evolution

Selection counteracts gene conversion to maintain adaptation in frogs that prey on toxic toads

Leptodactylus fuscus

Genetic adaptation in New York City Rats (bioRxiv)

See press coverage of this work at Nature, The Guardian, New York Post, The Sun and The Independent. 


Genetic divergence between regions of a tumor reflects the mode of evolution (Nature Genetics)


Polymorphism levels in serial transfer evolution experiments (Evolution);  also described with clarity in a Stanford CEHG blog post by Dr. Doc Edge.

LD between >2 sites and clonal interference (Royal Society Interface)